Vladimir Kashuba

Thursday, 31st August 2017, 01:08
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Position: Principal  investigator in the Department of Microbiology, Tumor and Cell Biology  of Karolinska Institute, Stockholm, Sweden. Head of the Molecular Oncogenetics Department, Institute of Molecular Biology and Genetics, NASU, Kyiv, Ukraine

Address: Box 280, Stockholm, S-171 77, Sweden

Phone: +46 8 52 48 67 37

Fax: +46 8 31 94 70

E-mail: vladimir.kashuba<AT>ki.se

1990 Ph.D. in Molecular Biology, Institute of Molecular Biology and Genetics, NASU, Kyiv, Ukraine.

2009 Doctor of Science (habilitation) in Molecular Biology, Institute of Molecular Biology and Genetics, NASU, Kyiv, Ukraine.

  Scientific interests: 

  • molecular biology
  • cancer
  • tumor suppressor genes
  • epigenetics 

  Professional membership: 

  • European Association of Cancer Research (Member) 

 Selected publications:

  1. Braga, V. Loginov, V. Senchenko, A. Kudryavtseva, A. Dmitriev, D.  Khodyrev, T. Pavlova, A.V. Rynditch, M.I. Lerman, V. Kashuba. Novel  Methylation-Dependent Markers/Tumor Suppressor Genes Involved in the  Development of Renal Cell Cancer. In: Horizons in Cancer Research, 2010,  Volume 42, Editors: Hiroto S. Watanabe, Nova Science Publishers, Inc.
  2. E.R. Zabarovsky, V. Senchenko, V. Loginov, T. Pavlova, V.  Zabarovska, A. Dmitriev, M. Lung, C.K. Panda, V. Kashuba, M.I. Lerman,  E.A. Braga.Positional Cloning of Tumor Suppressor Genes from 3p21.3  Involved in Major Human Cancers. In: Horizons in Cancer Research, 2010,  Volume 42, Editors: Hiroto S. Watanabe, Nova Science Publishers, Inc.
  3. Braga E, Loginov W, Khodyrev D, Pronina I, Kazubskaya T,  Bogatyrova O, Kashuba VI, Senchenko VN, Klein G, Lerman MI, Kisselev LL,  Zabarovsky ER. A novel MECA3 region in human 3p21.3 harboring putative  tumor suppressor genes and oncogenes. Exp Oncol. 2011 Mar;33(1):33-41.
  4. Law EW, Cheung AK, Kashuba VI, Pavlova TV, Zabarovsky ER, Lung HL,  Cheng Y, Chua D, Lai-Wan Kwong D, Tsao SW, Sasaki T, Stanbridge EJ,  Lung ML. Anti-angiogenic and tumor-suppressive roles of candidate  tumor-suppressor gene, Fibulin-2, in nasopharyngeal carcinoma. Oncogene.  2011 Jul 11. 272.
  5. Kondratov AG, Stoliar LA, Kvasha SM, Gordiyuk VV, Zgonnyk YM,  Gerashchenko AV, Vozianov AF, Rynditch AV, Zabarovsky ER, Kashuba VI.  Methylation pattern of the putative tumor-suppressor gene LRRC3B  promoter in clear cell renal cell carcinomas. Mol Med Report. 2012  Feb;5(2):509-512.
  6. Yenamandra SP, Darekar SD, Kashuba V, Matskova L, Klein G, Kashuba  E. Stem cell gene expression in MRPS18-2-immortalized rat embryonic  fibroblasts. Cell Death Dis. 2012 Jan 19;3:e357.
  7. Haraldson K, Kashuba VI, Dmitriev AA, Senchenko VN, Kudryavtseva  AV, Pavlova TV, Braga EA, Pronina IV, Kondratov AG, Rynditch AV, Lerman  MI, Zabarovsky ER. LRRC3B gene is frequently epigenetically inactivated  in several epithelial malignancies and inhibits cell growth and  replication. Biochimie. 2012 May;94(5):1151-1157.
  8. Flaberg E, Guven H, Savchenko A, Pavlova T, Kashuba V, Szekely L,  Klein G. The architecture of fibroblast monolayers of different origin  differentially influences tumor cell growth. Int J Cancer. 2012 Mar 7.  doi: 10.1002/ijc.27521.
  9. Dmitriev AA, Kashuba VI, Haraldson K, Senchenko VN, Pavlova TV,  Kudryavtseva AV, Anedchenko EA, Krasnov GS, Pronina IV, Loginov VI,  Kondratieva TT, Kazubskaya TP, Braga EA, Yenamandra SP, Ignatjev I,  Ernberg I, Klein G, Lerman MI, Zabarovsky ER. Genetic and epigenetic  analysis of non-small cell lung cancer with NotI-microarrays.  Epigenetics. 2012 May 1;7(5).
  10. Mostovich LA, Prudnikova TY, Kondratov AG, Gubanova NV,  Kharchenko OA, Kutsenko OS, Vavilov PV, Haraldson K, Kashuba VI, Ernberg  I, Zabarovsky ER, Grigorieva EV. The TCF4/β-catenin pathway and  chromatin structure cooperate to regulate D-glucuronyl C5-epimerase  expression in breast cancer. Epigenetics. 2012 Aug;7(8):930-9. doi:  10.4161/epi.21199.