Ivan Rusyn

Thursday, 31st August 2017, 01:37
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Position: M.D., Ph.D., Professor of the Environmental Sciences and Engineering Department in University of North Carolina.

Address: 0031 MHRC, CB#7431, Chapel Hill, NC, 27599, USA

Phone: 8-10-1-919-843-2596

Home page: go to >>


1994 M.D., Ukrainian State Medical University, Kyiv, Ukraine (with Honors).
2000 Ph.D. in Toxicology, University of North Carolina at Chapel Hill.

Scientific interests:

  • Toxicology
  • Environmental Health

Honors and awards:

  • 2008 Achievement Award, Society of Toxicology
  • 2002-2005 Transition to Independent Position Award, NIEHS
  • 2000-2002 Individual Postdoctoral National Research Service Award, NIEHS
  • 2000-2001 Leon & Bertha Golberg Memorial Postdoctoral Fellowship, UNC-Chapel Hill
  • 2000 Visiting Professor of Surgery, Yamanashi Medical University, Japan
  • 2000 Young Investigator Award, Soc. for Free Radical Research International
  • 2000 AACR - Bristol Myers Squibb Oncology Young Investigator Scholar Award
  • 2000 Carl C. Smith Mechanisms Specialty Section Award, Society of Toxicology
  • 1998/99/2001 Young Investigator Award, Oxygen Society
  • 1995-1996 Research Fellowship, German Academic Exchange Service (DAAD)
  • 1994 First Class Honors Diploma, Ukrainian State Medical University, Kiev, Ukraine

Professional membership:

  • Society of Toxicology (1997 - )
  • Society for Free Radical Biology and Medicine (1998 - 2007)
  • Society for Free Radical Research International (1998 - 2007)
  • American Society for Pharmacology and Experimental Therapeutics (2011 - )

Member of editorial boards:

  • Toxicological Sciences
  • Toxicology & Applied Pharmacology

Selected publications:

  1. Low, Y., Uehara, T., Minowa, Y., Yamada, H., Ohno, Y., Urushidani, T., Sedykh, A., Muratov, E., Kuz'min, V., Fourches, D., Zhu, H., *Rusyn, I., and Tropsha, A. Predicting drug-induced hepatotoxicity using QSAR and toxicogenomics approaches. Chem Res Toxicol 24:1251-1262, 2011. *Corresponding author.
  2. Gatti, D.M., Lu, L., Williams, R.W., Sun, W., Wright, F.A., Threadgill, D.W., and Rusyn, I.MicroRNA expression in the livers of inbred mice. Mutat Res714:126-133, 2011.
  3. Grosse, Y., Baan, R., Secretan-Lauby, B., El Ghissassi, F., Bouvard, V., Benbrahim-Tallaa, L., Guha, N., Islami, F., Galichet, L., Straif, K.; WHO International Agency for Research on Cancer Monograph Working Group. Carcinogenicity of chemicals in industrial and consumer products, food contaminants and flavourings, and water chlorination byproducts. Lancet Oncol 12:328-329, 2011.
  4. Koturbash, I., Scherhag, A., Sorrentino, J., Sexton, K., Bodnar, W., Tryndyak, V., Latendresse, J.R., Swenberg, J.A., Beland, F.A., Pogribny, I.P., and Rusyn, I. Epigenetic alterations in liver of C57BL/6J mice after short-term inhalational exposure to 1,3-butadiene. Environ Health Persp119:635-640, 2011.
  5. Koturbash, I., Scherhag, A., Sorrentino, J., Sexton, K., Bodnar, W., Swenberg, J.A., Beland, F.A., Pardo-Manuel deVillena, F., *Rusyn, I., and Pogribny, I.P. Epigenetic mechanisms of mouse inter-strain variability in genotoxicity of the environmental toxicant 1,3-butadiene. Toxicol Sci122:448-456, 2011. *Equally contributing senior author.
  6. Sedykh, A., Zhu, H., Tang, H., Zhang, L., Richard, A., *Rusyn I., and Tropsha A.Use of in vitro HTS-derived concentration-response data as biological descriptors improves the accuracy of QSAR models of in vivotoxicity. Environ Health Persp 119:364-370, 2011. *Equally contributing senior author.
  7. Bradford, B.U., Lock, E.F., Kosyk, O., Kim, S.K., Uehara, T., Harbourt, D., DeSimone, M., Threadgill, D.W., Tryndyak, V., Pogribny, I.P., Bleyle, L., Koop, D.R. and Rusyn, I. Inter-strain differences in the liver effects of trichloroethylene in a multi-strain panel of inbred mice. Toxicol Sci 120:206-217, 2011.
  8. O’Shea, S.H., Schwarz, J., Kosyk, O., Ross, P.K., Ha, M.J., Wright, F.A., and Rusyn, I. In vitroscreening for population variability in chemical toxicity.Toxicol Sci 119:398-407, 2011.
  9. Jeannot, E., Pogribny, I.P., Beland, F.A., and Rusyn, I. Chronic administration of ethanol leads to an increased incidence of hepatocellular adenoma by promoting H-ras-mutated cells. Cancer Lett 301:161–167, 2011.
  10. Formeister, E.J., Tsuchiya, M., Fujii, H., Shpyleva, S., Pogribny, I., and Rusyn, I. Comparative analysis of promoter methylation and gene expression endpoints between tumorous and non-tumorous tissues from HCV-positive patients with hepatocellular carcinoma. Mutat Res: vol.692, p.26-33, 2010.
  11. Gatti, D.M., Zhao, N., Chesler, E.J., Bradford, B.U., Shabalin, A., Yordanova, R., Lu, L., and Rusyn, I. Sex-specific gene expression in BXD mouse liver. Physiol Genomics: vol.42, p.456-468, 2010.
  12. Rusyn. I., Gatti, D.M., Wiltshire, T., Kleeberger, S.R., and Threadgill, D.W. Toxicogenetics: population-based testing of drug and chemical safety in mouse models. Pharmacogenomics: vol.11, p.1127-1136, 2010.
  13. Rusyn. I., and Daston, G.P. Computational Toxicology: Realizing the Promise of the Toxicity Testing in the 21st Century. Environ Health Perspect: vol.118, p.1047-1050, 2010.
  14. Tsuchiya, M., Parker, J., Kono, H., Matsuda, M., Fujii, H., and Rusyn, I. Gene expression in nontumoral liver tissue and recurrence-free survival in hepatitis C virus-positive hepatocellular carcinoma. Mol Cancer: vol.9, p.74, 2010.
  15. Pogribny, I.P., Rusyn, I. and Beland, F.A. Epigenetic aspects of genotoxic and non-genotoxic hepatocarcinogenesis: Studies in rodents. Environ Mol Mutagen 49(1):9-15, 2008.
  16. Rusyn, I., Fry, R.C., Begley, T.J., Klapacz, J., Svensson, J.P., Ambrose, M., and Samson, L.D. Transcriptional networks in S. cerevisiae linked to an accumulation of base excision repair intermediates. PLoS ONE 2:e1252, 2007.
  17. Pogribny, I.P., Tryndyak, V.P., Woods, C.G., Witt, S.E., and Rusyn, I. Epigenetic effects of the continuous exposure to peroxisome proliferator WY-14,643 in mouse liver are dependent upon peroxisome proliferator activated receptor α. Mutat Res 625:62-71, 2007.
  18. Woods, C.G., Kosyk, O., Bradford, B.U., Ross, P.K., Burns, A.M., Cunningham, M.L., Qu, P., Ibrahim, J.G. and Rusyn I. Gene expression in mouse liver reveals a temporal shift in molecular pathways that mediate effects of peroxisome proliferators. Toxicol Appl Pharmacol 225:267-277, 2007.
  19. Peffer, R., Moggs, J.G., Pastoor, T., Currie, R.A., Wright, J., Millburn, G., Waechter, F., and Rusyn, I. Mouse liver effects of Cyproconazole, a triazole fungicide: Role of the constitutive androstane receptor. Toxicol Sci 99:315-325, 2007.
  20. Beyer, R., et al. Multi-center study of acetaminophen hepatotoxicity reveals the critical importance of biological endpoints in genomic analyses. Toxicol Sci 99:326-337, 2007.
  21. Roberts, A., McMillan, L., Wang, W., Parker, J., Rusyn, I., and Threadgill, D. Inferring missing genotypes in large SNP panels using fast nearest-neighbor searches over sliding windows. Bioinformatics 23:i401-i407, 2007.
  22. Gatti, D., Maki, A., Chesler, E.J., Kirova, R., Lu, L., Wang, J., Williams, R.W., Perkins, A., Langston, M.A., Threadgill, D.W., and Rusyn, I. Genome-level analysis of genetic regulation of liver gene expression networks. Hepatology 46:548-557, 2007.
  23. Woods, C.G., Burns, A.M., Bradford, B.U., Ross, P.K., Kosyk, O., Swenberg, J.A., Cunningham, M.L., and Rusyn I. WY-14,643-induced cell proliferation and oxidative stress in mouse liver are independent of NADPH oxidase. Toxicol Sci 98:366-74, 2007.
  24. Woods, C.G., Vanden Heuvel, J.P., and Rusyn, I. Genomic profiling in nuclear receptor-mediated toxicity. Toxicol Pathol 35:474-494, 2007.
  25. Hammond, L.E., Albright, C.D., He, L., Rusyn, I., Watkins, S.M., Doughman, S.D., Lemasters, J.J., and Coleman, R.A. Increased oxidative stress is associated with balanced increases in hepatocyte apoptosis and proliferation in glycerol-3-phosphate acyltransferase-1 deficient mice. Exp Mol Pathol 82:210-219, 2007.
  26. Maki, A., Kono, H., Gupta, M., Asakawa, M., Suzuki, T., Matsuda, M., Fujii, H., and Rusyn, I.Predictive power of biomarkers of oxidative stress and inflammation in patients with hepatitis C virus-associated hepatocellular carcinoma. Ann Surg Oncol 14:1182-90, 2007.
  27. Roberts, R.A., Ganey, P.E., Ju, C., Kamendulis, L.M., Rusyn, I., and Klaunig, J.E. Role of the Kupffer cell in mediating hepatic toxicity and carcinogenesis. Toxicol Sci 96:2-15, 2007.
  28. Woods, C.G., Burns, A.M., Maki, A., Bradford, B.U., Cunningham, M.L., Connor, H.D., Kadiiska, M., Mason, R.P., Peters, J.M., and Rusyn, I. Sustained formation of α-(4-pyridyl-1-oxide)-N-tert-butylnitrone radical adducts in mouse liver by peroxisome proliferators is dependent upon peroxisome proliferator-activated receptor-α, but not NADPH oxidase. Free Radic Biol Med 42:335-342, 2007.
  29. Pogribny, I.P., Tryndyak, V.P., Muskhelishvili, L., Rusyn, I., and Ross, S.A. Methyl deficiency, alterations in global histone modifications and carcinogenesis. J Nutr 137:216S-222S, 2007. 16. Yamashina S, Ikejima K, Rusyn I, Sato N. Glycine as a potent anti-angiogenic nutrient for tumor growth. J Gastroenterol Hepatol. 22:S62-64, 2007.