Volodymyr Tryndyak

Monday, 25th September 2017, 03:05
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Position: Staff fellow of the Division of Biochemical Toxicology at the National Center for Toxicological Research.
Address: 3900 NCTR Rd, HFT-140, Jefferson, AR 72079 USA
Phone: 011-870-543-7545
Fax: 011-870-543-7610
Home page: go to >>
E-mail: volodymyr.tryndyak<AT>fda.hhs.gov

1998 M.Sc. in Biochemistry, Ivan Franko National University of Lviv, Lviv, Ukraine. 

2004 Ph.D. in Oncology, R.E.Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology of the National Academy of Sciences of Ukraine, Kyiv, Ukraine.

Scientific interests: 

  • Genetics and epigenetics of cancer
  • Multidrug resistance in cancer

Honors and awards: 

  • 2001 Presidential Scholarship Award for Young Scientists, Kyiv, Ukraine. 
  • 2004 Post-doctoral Fellowship, Oak Ridge Institute for Science and Education, Oak Ridge, TN, USA. 

Professional membership: 

  • American Association for Cancer Research (Associate member) 
  • Society of Toxicology (Fellow) 

Selected publications:

  1. Guariento A.H., Furtado K.S., de Conti A., Campos A., Purgatto E., Carrilho J., Shinohara E.M., Tryndyak V., Han T., Fuscoe J.C., Ross S.A., Beland F.A., Pogribny I.P., Moreno F.S. Transcriptomic responses provide a new mechanistic basis for the chemopreventive effects of folic acid and tributyrin in rat liver carcinogenesis. Int. J. Cancer. 2013 Dec 3. (in press).
  2. Chappell G., Kutanzi K., Uehara T., Tryndyak V., Hong H.H., Hoenerhoff M., Beland F.A., Rusyn I., Pogribny I.P. Genetic and epigenetic changes in fibrosis-associated hepatocarcinogenesis in mice. Int. J. Cancer. 2013: (in press).
  3. de Conti A., Tryndyak V., Koturbash I., Heidor R., Kuroiwa-Trzmielina J., Ong T.P., Beland F.A., Moreno F.S., Pogribny I.P. The chemopreventive activity of the butyric acid prodrug tributyrin in experimental rat hepatocarcinogenesis is associated with p53 acetylation and activation of the p53 apoptotic signaling pathway. Carcinogenesis. 2013; 34(8): 1900-1906.
  4. Pogribny I.P., Tryndyak V.P., Pogribna M., Shpyleva S., Surratt G., Gamboa da Costa G., Beland F.A. Modulation of intracellular iron metabolism by iron chelation affects chromatin remodeling proteins and corresponding epigenetic modifications in breast cancer cells and increases their sensitivity to chemotherapeutic agents. Int. J. Oncol. 2013; 42(5): 1822-1832.
  5. Pogribny I.P., Kutanzi K., Melnyk S., de Conti A., Tryndyak V., Montgomery B., Pogribna M., Muskhelishvili L., Latendresse J.R., James S.J., Beland F.A., Rusyn I. Strain-dependent dysregulation of one-carbon metabolism in male mice is associated with choline- and folate-deficient diet-induced liver injury. FASEB J. 2013; 27(6): 2233-2243.
  6. Uehara T., Kosyk O., Jeannot E., Bradford B.U., Tech K., Macdonald J.M., Boorman G.A., Chatterjee S., Mason R.P., Melnyk S.B., Tryndyak V.P., Pogribny I.P., Rusyn I. Acetaminophen-induced acute liver injury in HCV transgenic mice. Toxicol. Appl. Pharmacol. 2013; 266(2): 224-232.
  7. Simpson N.E., Tryndyak V.P., Pogribna M., Beland F.A., Pogribny I.P. Modifying metabolically sensitive histone marks by inhibiting glutamine metabolism affects gene expression and alters cancer cell phenotype. Epigenetics. 2012; 7(12): 1413-1420.
  8. Tryndyak V., de Conti A., Kobets T., Kutanzi K., Koturbash I., Han T., Fuscoe J.C., Latendresse J.R., Melnyk S., Shymonyak S., Collins L., Ross S.A., Rusyn I., Beland F.A., Pogribny I.P. Interstrain differences in the severity of liver injury induced by a choline- and folate-deficient diet in mice are associated with dysregulation of genes involved in lipid metabolism. FASEB J. 2012; 26(11): 4592-4602.
  9. Tryndyak V.P., Latendresse J.R., Montgomery B., Ross S.A., Beland F.A., Rusyn I., Pogribny I.P. Plasma microRNAs are sensitive indicators of inter-strain differences in the severity of liver injury induced in mice by choline- and folate-deficient diet. Toxocol. Appl. Pharmacology. 2012; 262(1): 52-59.
  10. Tsuchiya M.Ji C., Kosyk O., Shymonyak S., Melnyk S., Kono H., Tryndyak V., Muskhelishvili L., Pogribny I.P., Kaplowitz N., Rusyn I. Inter-strain differences in liver injury and one-carbon metabolism in alcohol-fed mice. Hepatology. 2012; 56(1): 130-139.